camera iphone 8 plus apk Ashim K. Mitra|University of Missouri-Kansas City School of Pharmacy|USA| Ophthamology 2014

Title:Emerging technologies in controlled long term delivery of ocular therapeutics

4th International Conference on
Clinical & Experimental Ophthalmology
July 14-16, 2014 DoubleTree by Hilton Baltimore, USA

OMICS International: http://omicsonline.org
Vaccine Conferences: http://conferenceseries.com/immunolog...
Global Medical Conferences: http://conferenceseries.com
Global Pharmaceutical Conferences: http://pharmaceuticalconferences.com
Global Cancer Conferences: http://cancersummit.org
Global Diabetes Conferences: http://diabetesexpo.com
Global Dental Conferences: http://dentalcongress.com
Global Nursing Conferences: http://nursingconference.com

Abstract:
Current macromolecular delivery in the treatment of diabetic retinopathy and wet-AMD (age-related macular degeneration) requires frequent intravitreal injections to maintain therapeutic levels at retina/choroid. Frequent intravitreal administrations can cause potential complications like endophthalmitis, retinal detachment, retinal hemorrhage, and patient noncompliance. Studies with marketed polymers (poly (lactic-co-glycolic acid) (PLGA)) suggest that acidic pH in the core of nanoparticles significantly reduces biological activity of therapeutic proteins. In our laboratory, we have recently developed and evaluated novel tailor-made pentablock (PB) copolymers for semi-invasive controlled delivery of therapeutic proteins to back of the eye tissues (retina-choroid). PB copolymers were synthesized utilizing various FDA approved biodegradable and biocompatible polymer blocks (polyglycolide (PGA), polyethylene glycol (PEG), polylactide (PLA) and polycaprolactone (PCL). These PB copolymers have been optimized with respect to molecular weight and ratios of each block in order to develop a successful macromolecular (model proteins such as lysozyme, BSA, IgG, and IgG-Fab) drug delivery system. High molecular weight PB copolymers with the block arrangement of PGA-PCL-PEG-PCL-PGA and PLA-PCL-PEG-PCL-PLA were utilized to prepare protein encapsulated nanoparticulate formulation. Whereas, PB copolymers with low molecular weight and different arrangement of blocks i.e., PEG-PCL-PLA-PCL-PEG were developed to formulate thermosensitive gel. In-vitro release studies performed with IgG-Fab and IgG-encapsulated nanoparticles exhibited copolymers in the development of drug delivery system which may not be limited to ocular formulations.



Biography:

Mitra received his Ph.D. in Pharmaceutical Chemistry in 1983 from the University of Kansas. He is currently a Curator’s Professor of Pharmacy at the University of Missouri-Kansas City. He is also the Vice Provost for Interdisciplinary Research and Chairman of the Division of Pharmaceutical Sciences, and Co-director of the Vision Research Center at the University of Missouri-Kansas City School of Medicine. He has conducted extensive research in various drug delivery technologies, including ocular drug delivery for the past three decades. He has published nearly 300 peer reviewed scientific research and review articles in high impact international journals. He has presented over 350 abstracts at scientific meetings, including the annual American Association of Pharmaceutical Scientists (AAPS), the Society of Toxicology, and The Association for Research in Vision and Ophthalmology (ARVO) conferences, and has given over 100 presentations to a wide audience (including several universities, pharmaceutical companies and scientific organizations).

camera iphone 8 plus apk Ashim K. Mitra|University of Missouri-Kansas City School of Pharmacy|USA| Ophthamology 2014
4 Likes	4 Dislikes
567 views views	79 followers
People & Blogs	Upload TimePublished on 25 Aug 2015

Related keywords

camera iphone x,camera iphone x vs xr,video phone beyonce mp3,video phone commax,free fonts,video phone screen,camera phone ranking,free robux,video phone letra,free ringtones,free people,freedom mortgage,free online games,free movies online,video phone wikipedia,video phone number,camera phone x - os 12 camera apk,freecell,video phone gaga,video phone beyonce lyrics,video phone é a continuação de telephone,freebirds,camera iphone 7 plus,camera iphone x apk,video phone beyonce letra,camera iphone apk,free movies,free dating sites,camera phone x apk,freestyle libre,free stock photos,camera iphone 8,video phone lyrics,camera iphone 7 vs iphone 8,free music,camera iphone 7,camera iphone 6,video phone ft lady gaga,free games,freep,video phone beyonce,camera phone x,video phone tradução,video phone extended remix,camera phone 2019,video phone call,video phone lady gaga,freeform,camera iphone xr vs xs,video phone feat lady gaga,camera iphone,camera phone comparison,video phone beyonce lady gaga,app video iphone,free vpn,camera iphone 8 plus,camera iphone xr,free credit report,free credit score,